The series featured many of the same actors who had starred on The Kids of Degrassi Street a few years earlier, including Stacie Mistysyn, Neil Hope, Anais Granofsky, Sarah Charlesworth and others. However, their character names and family situations had been changed, so Degrassi Junior High cannot, therefore, be considered a direct spinoff.

The legal counsel for all the episodes was Stephen Stohn who later became the executive producer of Degrassi: The Next Generation. The series was filmed at the unused Vincent Massey Public School in Etobicoke, Ontario.